WS14.2 Tolerability of inhaled dry powder Bronchitol (mannitol)
نویسندگان
چکیده
منابع مشابه
A pilot study of inhaled dry-powder mannitol during cystic fibrosis-related pulmonary exacerbation.
Pulmonary exacerbation treatment aims to eradicate increased respiratory symptoms and recover acute loss in lung function. Current treatment strategies remain suboptimal, with conventional intravenous antibiotics and intensive physiotherapy failing to achieve this in 25% of patients [1]. Despite this worrying statistic, optimising recovery from acute pulmonary exacerbations has not been a focus...
متن کاملLong-term inhaled dry powder mannitol in cystic fibrosis: an international randomized study.
RATIONALE New treatment strategies are needed to improve airway clearance and reduce the morbidity and the time burden associated with cystic fibrosis (CF). OBJECTIVES To determine whether long-term treatment with inhaled mannitol, an osmotic agent, improves lung function and morbidity. METHODS Double-blind, randomized, controlled trial of inhaled mannitol, 400 mg twice a day (n = 192, "tre...
متن کاملInhaled dry powder mannitol in cystic fibrosis: an efficacy and safety study.
This international phase III study of inhaled dry powder mannitol was a randomised, double-blind, 26-week study, followed by a further 26-week, open-label (OL) extension. 324 cystic fibrosis (CF) patients were randomised, in a 3:2 ratio, to mannitol (400 mg b.i.d.) and control groups. The primary efficacy end-point was to determine the change in forced expiratory volume in 1 s (FEV₁) over the d...
متن کاملInhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial.
INTRODUCTION Inhaled mannitol has beneficial effects on lung function, mucociliary clearance, quality of life and sputum properties. This trial examined the efficacy of inhaled mannitol in children with cystic fibrosis (CF). METHODS The efficacy of inhaled mannitol in children with CF aged 6-17years was assessed in a phase 2, randomised, placebo-controlled crossover study. Subjects were rando...
متن کاملInhaled Therapeutics using Dry Powder Inhalers (DPI)
Dry powder inhalers (DPIs), opposed to the traditional pre-metered dose inhalers (MDIs), prove to be more advantageous in delivering the desired dosage of medication to the targeted site. Now, engineers are designing better DPIs and new carrier particles that have better characteristics for drug delivery.
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2014
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(14)60089-8